The People of the Olin Neuropsychiatry Research Center

David C Glahn, Ph.D Director, Affective Disorders and Psychosis Trials Imaging, Neuropsychology & Genetics Laboratory Olin Neuropsychiatry Research Center Associate Professor Department of Psychiatry Yale University School of Medicine 200 Retreat Avenue Whitehall Building - Institute of Living Hartford CT 06106 Phone: 860-545-7700, ext 7552 Email: david.glahn@yale.edu Lab Web page: www.glahngroup.org

Who Am I?

Dr. David Glahn joined the Olin Neuropsychiatry Research Center, Institute of Living, and the Department of Psychiatry, Yale University School of Medicine in October of 2008. He received his doctorate in psychology from the University of Pennsylvania in 2000 and completed a post-doctoral fellowship at the University of California at Los Angeles (UCLA). From 2002 until 2008, Glahn was part of the Department of Psychiatry and the Research Imaging Center, University of Texas Health Science Center San Antonio. Glahn’s research focuses on elucidating the neurobiological roots of major mental illnesses through the integration of cognitive neuropsychological, functional and structural neuroimaging, and behavioral and molecular genetic approaches. The ultimate goals of this research is the identification of genes involved in affective and psychotic illnesses as well as genes that influence non-pathological brain structure and function. Localization of genes involved in mental illness should significantly contribute to an understanding of the underlying biology of these complex diseases, which in turn should improve future treatments and create the potential for prevention strategies.

Roles and Responsibilities

• Lead the ADAPTING Laboratory

• Formulate & plan new psychiatric genetic and imaging research studies

• Integrate clinical, genetic, neurocognitive & neuroimaging data.

• Educate researchers, graduate and medical students.

Objectives/Interests in Neuropsychiatry:

• Localize genes influencing affective and psychotic illnesses

• Localize genes influencing brain structure and function

• Develop quantitative endophenotypes for affective and psychotic illnesses

Current Projects:

• Influence of Psychosis on Brain-Behavior Endophenotypes for Bipolar Disorder

• Genetics of Brain Structure and Function

• Genetics of Brain Structure and Function: Genome Wide Association

• Genetics of Bipolar Disorder in Latino Populations

• Neuropsychological and Neuroimaging Abnormalities in Siblings Pairs Discordant for Bipolar Disorder

• Neuropsychological Predictors of Functional Outcome in Bipolar Disorder

• Neuropsychological Correlates of Bipolar Disorder

• Affective & Neurobiological Predictors of Adolescent-Onset Alcohol Use Disorders

Publications (since Jan 1, 2008)

Acute citalopram administration may disrupt contextual information processing in healthy males. Almeida S, Glahn DC, Argyropoulos SV, Frangou S. Eur Psychiatry. 2009 Aug 18.

Meta-analysis of 41 functional neuroimaging studies of executive function in schizophrenia. Minzenberg MJ, Laird AR, Thelen S, Carter CS, Glahn DC. Arch Gen Psychiatry. 2009 Aug;66(8):811-22.

Correspondence of the brain's functional architecture during activation and rest. Smith SM, Fox PT, Miller KL, Glahn DC, Fox PM, Mackay CE, Filippini N, Watkins KE, Toro R, Laird AR, Beckmann CF. Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):13040-5.

Metaanalytic connectivity modeling: Delineating the functional connectivity of the human amygdala. Robinson JL, Laird AR, Glahn DC, Lovallo WR, Fox PT. Hum Brain Mapp. 2009 Jul 14.

Amygdala hyperactivation in untreated depressed individuals. Peluso MA, Glahn DC, Matsuo K, Monkul ES, Najt P, Zamarripa F, Li J, Lancaster JL, Fox PT, Gao JH, Soares JC. Psychiatry Res. 2009 Aug 30;173(2):158-61.

Fronto-temporal dysregulation in remitted bipolar patients: an fMRI delayed-non-match-to-sample (DNMS) study. Robinson JL, Bearden CE, Monkul ES, Tordesillas-Gutiérrez D, Velligan DI, Frangou S, Glahn DC. Bipolar Disord. 2009 Jun;11(4):351-60.

Prefrontal activation deficits during episodic memory in schizophrenia. Ragland JD, Laird AR, Ranganath C, Blumenfeld RS, Gonzales SM, Glahn DC. Am J Psychiatry. 2009 Aug;166(8):863-74.

Heritability of age of onset of psychosis in schizophrenia. Hare E, Glahn DC, Dassori A, Raventos H, Nicolini H, Ontiveros A, Medina R, Mendoza R, Jerez A, Muñoz R, Almasy L, Escamilla MA. Am J Med Genet B Neuropsychiatr Genet. 2009 Apr 6.

Conceptualizing impulsivity and risk taking in bipolar disorder: importance of history of alcohol abuse. Kathleen Holmes M, Bearden CE, Barguil M, Fonseca M, Serap Monkul E, Nery FG, Soares JC, Mintz J, Glahn DC. Bipolar Disord. 2009 Feb;11(1):33-40.

Differential activation of the anterior cingulate cortex and caudate nucleus during a gambling simulation in persons with a family history of alcoholism: studies from the Oklahoma Family Health Patterns Project. Acheson A, Robinson JL, Glahn DC, Lovallo WR, Fox PT. Drug Alcohol Depend. 2009 Feb 1;100(1-2):17-23. Epub 2008 Nov 20.

The serotonin transporter 5-HTTPR polymorphism is associated with current and lifetime depression in persons with chronic psychotic disorders. Contreras J, Hare L, Camarena B, Glahn D, Dassori A, Medina R, Contreras S, Ramirez M, Armas R, Munoz R, Mendoza R, Raventos H, Ontiveros A, Nicolini H, Palmer R, Escamilla M. Acta Psychiatr Scand. 2009 Feb;119(2):117-27

Increased extent of object-selective cortex in schizophrenia. Wynn JK, Green MF, Engel S, Korb A, Lee J, Glahn D, Nuechterlein KH, Cohen MS. Psychiatry Res. 2008 Nov 30;164(2):97-105. Epub 2008 Oct 19.

Fronto-limbic circuitry in euthymic bipolar disorder: evidence for prefrontal hyperactivation. Robinson JL, Monkul ES, Tordesillas-Gutiérrez D, Franklin C, Bearden CE, Fox PT, Glahn DC. Psychiatry Res. 2008 Nov 30;164(2):106-13. Epub 2008 Oct 19.

Cognitive impairment in bipolar disorder: neurodevelopment or neurodegeneration? An ECNP expert meeting report. Goodwin GM, Martinez-Aran A, Glahn DC, Vieta E. Eur Neuropsychopharmacol. 2008 Nov;18(11):787-93. Epub 2008 Aug 24.

Psychiatric neuroimaging: joining forces with epidemiology. Glahn D, Reichenberg A, Frangou S, Ormel H. Eur Psychiatry. 2008 Jun;23(4):315-9. Epub 2008 Jun 16.

Meta-analysis of gray matter anomalies in schizophrenia: application of anatomic likelihood estimation and network analysis. Glahn DC, Laird AR, Ellison-Wright I, Thelen SM, Robinson JL, Lancaster JL, Bullmore E, Fox PT. Biol Psychiatry. 2008 Nov 1;64(9):774-81.

Verbal recall and recognition in twins discordant for schizophrenia. van Erp TG, Therman S, Pirkola T, Tuulio-Henriksson A, Glahn DC, Bachman P, Huttunen MO, Lönnqvist J, Hietanen M, Kaprio J, Koskenvuo M, Cannon TD. Psychiatry Res. 2008 Jun 30;159(3):271-80.

Neural phenotypes of common and rare genetic variants. Bearden CE, Glahn DC, Lee AD, Chiang MC, van Erp TG, Cannon TD, Reiss AL, Toga AW, Thompson PM. Biol Psychol. 2008 Sep;79(1):43-57. Epub 2008 Feb 23.

The anatomy of first-episode and chronic schizophrenia: an anatomical likelihood estimation meta-analysis. Ellison-Wright I, Glahn DC, Laird AR, Thelen SM, Bullmore E. Am J Psychiatry. 2008 Aug;165(8):1015-23. Epub 2008 Apr 1.

Comparing the efficacy of interventions that use environmental supports to improve outcomes in patients with schizophrenia. Velligan DI, Diamond PM, Maples NJ, Mintz J, Li X, Glahn DC, Miller AL. Schizophr Res. 2008 Jul;102(1-3):312-9. Epub 2008 Apr 18.

A collaborative knowledge base for cognitive phenomics. Sabb FW, Bearden CE, Glahn DC, Parker DS, Freimer N, Bilder RM. Mol Psychiatry. 2008 Apr;13(4):350-60. Epub 2008 Jan 8.

The central sulcus: an observer-independent characterization of sulcal landmarks and depth asymmetry. Cykowski MD, Coulon O, Kochunov PV, Amunts K, Lancaster JL, Laird AR, Glahn DC, Fox PT. Cereb Cortex. 2008 Sep;18(9):1999-2009. Epub 2007 Dec 10.

Subtle cognitive dysfunction in nonaffected siblings of individuals affected by nonpsychotic disorders. Weiser M, Reichenberg A, Kravitz E, Lubin G, Shmushkevich M, Glahn DC, Gross R, Rabinowitz J, Noy S, Davidson M. Biol Psychiatry. 2008 Mar 15;63(6):602-8. Epub 2007 Sep 7.

Relationships among subjective and objective measures of adherence to oral antipsychotic medications. Velligan DI, Wang M, Diamond P, Glahn DC, Castillo D, Bendle S, Lam YW, Ereshefsky L, Miller AL. Psychiatr Serv. 2007 Sep;58(9):1187-92.

Three-dimensional mapping of hippocampal anatomy in unmedicated and lithium-treated patients with bipolar disorder. Bearden CE, Thompson PM, Dutton RA, Frey BN, Peluso MA, Nicoletti M, Dierschke N, Hayashi KM, Klunder AD, Glahn DC, Brambilla P, Sassi RB, Mallinger AG, Soares JC. Neuropsychopharmacology. 2008 May;33(6):1229-38.

Temperament and character traits in patients with bipolar disorder and associations with comorbid alcoholism or anxiety disorders. Nery FG, Hatch JP, Glahn DC, Nicoletti MA, Monkul ES, Najt P, Fonseca M, Bowden CL, Cloninger CR, Soares JC. J Psychiatr Res. 2008 Jun;42(7):569-77.